Patient diagnosed with breast cancer recurrence and planned to repeat the surgery will be enrolled to evaluate the accuracy of a dual tracer method in detecting sentinel lymph nodes and understanding lymphatic drainage

Validation of dual tracer Sentinel Lymph node biopsy in patients with non-metastatic in-breast tumour recurrence undergoing Re-surgery and study of lymphatic drainage pathways (SLR study) - SLR Study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/11/098114

Enrollment

110

Registered

2025-11-26

Start date

Unknown

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: SLN biopsy with clearance: SN biopsy with two dyes will be done and pathology assessment will be done on table during surgery and all patients will also have a complete clearance as per

Eligibility

Inclusion criteria

Inclusion criteria: 1. All patients with histologically proven ipsilateral breast tumourrecurrence (non-metastatic) who have undergone SLNB or low axillary sampling (LAS) or ALND in their index surgery. 2. IBTR patients undergoing upfront surgery or post-chemotherapy surgery (re-BCS or completion mastectomy) 3. Above 18 years 4. ECOG 0-2 5. Able to give written informed consent 6. Fit for surgery

Exclusion criteria

Exclusion criteria: 1. Pregnant, lactating women 2. Patients allergic to methylene blue dye / radio colloid injection

Design outcomes

Primary

Measure	Time frame
1. False Negative Rate Timepoint: After surgery	—

Secondary

Measure	Time frame
1. Identification rate of SLNB 2. Identification of first echelon SNB after previous breast surgery Timepoint: after surgery	—

Countries

India

Contacts

Public ContactShabina Siddique

Tata Memorial Centre

drshalakajoshi@gmail.com02224177198

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026