Comparative evaluation of Albumin Platelet-Rich Fibrin and Advanced Platelet-Rich Fibrin in periodontal regeneration: A clinical and radiological study

Comparative Evaluation of Albumin Platelet-Rich Fibrin and Advanced Platelet-Rich Fibrin in Periodontal Regeneration: A Clinical and Radiological Study - Alb-PRF vs A-PRF : RCT

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/11/098076

Enrollment

Registered

2025-11-25

Start date

Unknown

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Albumin Platelet-Rich Fibrin (Alb-PRF): 10 patients treated with Albumin Platelet-Rich Fibrin (Alb-PRF) in periodontal intrabony defects using the standard protocol. Control Interven

Eligibility

Inclusion criteria

Inclusion criteria: Stage III Periodontitis Diagnosis: Patients with moderate to severe periodontitis with at least one tooth exhibiting a two-wall, three-wall, or combined two- and three-wall intrabony defect measuring greater than or equal to 3 mm in depth. Clinical Attachment Loss and Pocket Depth: Presence of CAL measuring greater than or equal to 5 mm and PPD measuring greater than or equal to 6 mm. Exclusion of Furcation Defects Vital Teeth Medication and Antibiotic History No Recent Periodontal Therapy Informed Consent Age Range: Only individuals aged 18 60 years. Patient Compliance Systemic Health Status: Participants must be systemically healthy

Exclusion criteria

Exclusion criteria: Patients undergoing orthodontic treatment Pregnant and breastfeeding women Menopausal and postmenopausal Smokers Teeth with mobility greater than Grade 1 Patients with systemic comorbidities (e.g., Type 2 diabetes mellitus, hypertension) Patients with a history of recent periodontal surgery

Design outcomes

Primary

Measure	Time frame
1. Clinical Attachment Level (CAL) Gain Measured using a UNC-15 periodontal probe at baseline, 3 months, and 6 months postoperatively to assess periodontal tissue regeneration. 2. Probing Pocket Depth (PPD) Reduction Evaluated at the same time intervals to determine the extent of periodontal healing and reduction in periodontal pocket depth. 3. Radiographic Bone Fill Assessed using Cone-Beam Computed Tomography (CBCT) to compare pre- and postoperative bone levels within intrabony defects. Timepoint: All primary outcomes are measured at baseline, 3 months, and 6 months postoperatively to assess periodontal tissue regeneration.	—

Measure

Time frame

1. Clinical Attachment Level (CAL) Gain Measured using a UNC-15 periodontal probe at baseline, 3 months, and 6 months postoperatively to assess periodontal tissue regeneration. 2. Probing Pocket Depth (PPD) Reduction Evaluated at the same time intervals to determine the extent of periodontal healing and reduction in periodontal pocket depth. 3. Radiographic Bone Fill Assessed using Cone-Beam Computed Tomography (CBCT) to compare pre- and postoperative bone levels within intrabony defects. Timepoint: All primary outcomes are measured at baseline, 3 months, and 6 months postoperatively to assess periodontal tissue regeneration.

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Secondary

Measure	Time frame
Early Soft Tissue HealingTimepoint: Evaluated using the Wound Healing Index (WHI) at 1st week, 2nd week, and 4th week postoperatively to assess the progression of soft tissue repair. ;Gingival Index (GI)Timepoint: Assessed to determine the degree of gingival inflammation tissue response at baseline, 3 months, and 6 months. ;Plaque Index (PI)Timepoint: Measured to evaluate biofilm accumulation and its impact on periodontal healing over time. ;Bleeding on Probing (BOP)Timepoint: Recorded at each follow-up visit to assess the degree of inflammation and vascular response;Bone Density AnalysisTimepoint: Assessed via CBCT at baseline, 3 months, and 6 months to evaluate changes in bone quality and mineralization;Crestal Bone Loss MeasurementTimepoint: Determined using standardized radiographic analysis to quantify marginal bone changes around the defect site.	—

Measure

Time frame

Early Soft Tissue HealingTimepoint: Evaluated using the Wound Healing Index (WHI) at 1st week, 2nd week, and 4th week postoperatively to assess the progression of soft tissue repair. ;Gingival Index (GI)Timepoint: Assessed to determine the degree of gingival inflammation tissue response at baseline, 3 months, and 6 months. ;Plaque Index (PI)Timepoint: Measured to evaluate biofilm accumulation and its impact on periodontal healing over time. ;Bleeding on Probing (BOP)Timepoint: Recorded at each follow-up visit to assess the degree of inflammation and vascular response;Bone Density AnalysisTimepoint: Assessed via CBCT at baseline, 3 months, and 6 months to evaluate changes in bone quality and mineralization;Crestal Bone Loss MeasurementTimepoint: Determined using standardized radiographic analysis to quantify marginal bone changes around the defect site.

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Countries

India

Contacts

Public ContactAmanda Antoinette Rebello

Kalinga Institute of Dental Sciences, KIIT (Deemed to be University)

amandarebello.97@gmail.com9004319565

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026