A study comparing two medicines, dexmedetomidine and fentanyl, to control the rise in heart rate and blood pressure during tube insertion for anesthesia

A COMPARATIVE STUDY OF DEXMEDITOMIDINE VERSUS FENTANYL FOR ATTENUATION OF HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/11/098069

Enrollment

Registered

2025-11-25

Start date

Unknown

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: A COMPARATIVE STUDY OF DEXMEDITOMIDINE VERSUS FENTANYL FOR ATTENUATION OF HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION: Name of intervention: Dexmedetomidine Type:

Eligibility

Inclusion criteria

Inclusion criteria: PATIENTS GIVING VALID INFORMED CONSENT ASA GRADE 1 AND 2 AGE BETWEEN 20 TO 60 YEARS OF AGE ELECTIVE SURGERIES UNDER GA

Exclusion criteria

Exclusion criteria: PATIENT REFUSAL ASA GRADE 3 AND 4 AGE LESS THAN 20 AND MORE THAN 60 PREGNANCY OBESITY FULL STOMACH AND EMERGENCY SURGERY PATIENTS SUFFERING FROM CARDIOVASCULAR DISEASES PATIENTS WITH METABOLIC DISORDERS PATIENS WITH DIFFICULT AIRWAY

Design outcomes

Primary

Measure	Time frame
TO STUDY THE COMPARISION OF DEXMEDITOMIDINE AND FENTANYL IN ATTENUATION OF HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATIONTimepoint: Hemodynamic parameters (HR, SBP, DBP, MAP) will be measured at: 1.Baseline (before study drug administration) 2.After study drug administration just before induction 3.Before laryngoscopy and intubation (pre-intubation) 4.During laryngoscopy 5.Immediately after intubation (0 minute) 6.1 minute after intubation 7.3 minutes after intubation 8.5 minutes after intubation 9.10 minutes after intubation	—

Measure

Time frame

TO STUDY THE COMPARISION OF DEXMEDITOMIDINE AND FENTANYL IN ATTENUATION OF HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATIONTimepoint: Hemodynamic parameters (HR, SBP, DBP, MAP) will be measured at: 1.Baseline (before study drug administration) 2.After study drug administration just before induction 3.Before laryngoscopy and intubation (pre-intubation) 4.During laryngoscopy 5.Immediately after intubation (0 minute) 6.1 minute after intubation 7.3 minutes after intubation 8.5 minutes after intubation 9.10 minutes after intubation

—

Secondary

Measure	Time frame
TO EVALUATE THE LEVEL OF ANALGESIA AND SEDATION IN THE POST OPERATIVE PERIODTimepoint: UNTIL 24 HOURS POST SURGERY	—

Countries

India

Contacts

Public ContactDR SHRI HARINI K

Vinayaka missions Kirupanandha Variyar Medical College , Salem - 636308

cruise2010.mmc@gmail.com9840623673

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026