Health Condition 1: I259- Chronic ischemic heart disease, unspecified
Conditions
Interventions
Intervention1: Colchicine Group: Based on Inclusion and Exclusion criteria patient will be started on Tab Colchicine 0.5mg once a day along with his/her usual drugs for secondary Coronary Artery Disea
Sponsors
Dr Akshaya Kamalashree
Eligibility
Inclusion criteria
Inclusion criteria: 1) angiographically proven coronary disease 2) clinically stable greater than 6 months Post CAD diagnosis on regular secondary CAD prevention medications 3) hsCRP greater than 2 mg/L 4) considered compliant with therapy and follow-up at 1 & 3 months 5) willing to provide consent to participate in the study
Exclusion criteria
Exclusion criteria: 1 ) Renal failure eGFR less than 50 ml per min per 1.73 m2 2 ) Liver failure 3 ) active infection 4 ) Blood dyscrasias 5 ) Auto immune disorders 6 ) on Glucocorticoid therapy 7 ) on Colchicine for gout 8 ) Heart failure LVEF lesser than 40 percent 9 ) Pregnant or breast feeding 10) on strong CYP3A4 ; p- glycoprotein inhibitors Azole antifungals , clarithromycin , Lopinavir
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To measure the effect of Colchicine in reducing hs-CRP levels and preventing major adverse cardiovascular events in patients with stable Coronary Artery DiseaseTimepoint: hsCRP value at baseline, and 90 days after initiation of drug therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| nilTimepoint: nil | — |
Countries
India
Contacts
Public ContactDr Akshaya Kamalashree
SRM Medical College Hospital and Research Centre
Outcome results
None listed