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A study comparing two throat sprays used during general anaesthesia to see which better prevents cough, sore throat, and hoarseness after surgery.

A clinical study of comparative evaluation of effect of benzydamine hydrochloride (0.15 percent) spray and lidocaine hydrochloride (10 percent) spray on endotracheal tube cuff on post-operative cough, sore throat and hoarseness of voice in patients undergoing general anaesthesia with endotracheal tube placement.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/098025
Enrollment
432
Registered
2025-11-25
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Benzydamine hydrochloride (0.15%) spray: 2 years. The study drug will be applied as two puffs directly to the endotracheal tube (ETT) cuff before induction of general anaesthesia. Contr

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 18 to 65 years 2. Patients of either gender 3. ASA physical status I-IV

Exclusion criteria

Exclusion criteria: 1. Pre-existing airway disorders such as chronic cough, recurrent sore throat, or chronic respiratory conditions including asthma or chronic obstructive pulmonary disease (COPD). 2. Known allergy to study drugs. 3. Anticipated difficult airway. 4. Pregnant or lactating women.

Design outcomes

Primary

MeasureTime frame
The incidence of postoperative sore throat, hoarseness of voice, and cough at predetermined postoperative time intervals(0,1,6,12,24 hours) after extubation, compared among patients receiving benzydamine hydrochloride (0.15%), lidocaine hydrochloride (10%), or normal saline spray applied to the endotracheal tube cuff.Timepoint: 2 years—

Secondary

MeasureTime frame
Evaluation of side effects (if any) associated with benzydamine hydrochloride (0.15%) and lidocaine hydrochloride (10%) sprays applied to the endotracheal tube cuff.Timepoint: 2 years—

Countries

India

Contacts

Public ContactVivek Maratha

SUBHARTI MEDICAL COLLEGE

drvivekmaratha@yahoo.co.in9837035415

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026