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comparision of tprf incorporated with two different antibiotics in gum therapy

Comparitive evaluation of ofloxacin incorporated tprf vs metronidazole incorporated tprf as an adjunct to non surgical periodontal therapy A randomized clinical trial - Nil

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/098023
Enrollment
10
Registered
2025-11-25
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: ofloxacin incorporated t-prf(titanium prf): 0.5ml of Ofloxacin to 5ml of blood sample will be taken in the titanium tubes and then it will be subjected to centrifugation at 3500rpm for

Sponsors

Dr Sarvapradha S S
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Moderate periodontitis with attachment loss of 3 4 mm probing depth less than or equal to 6 and bleeding on probing 2.Systemically healthy patients 3.Patients age from 25-50 years 4.No history of periodontal therapy, either surgical or non-surgical in the previous six months. 5.Patient who have agreed to participate in the study

Exclusion criteria

Exclusion criteria: 1.Smokers 2.Pregnancy and lactating women 3.Systemic and debilitating diseases 4.Use of antibiotics during the last six months. 5.A previous unfavourable response to the study s products. 6.Patients with bleeding disorders 7.Patients taking antiplatelet therapy and anticoagulant therapy 8.Patients with severe hepatic impairment or renal disease

Design outcomes

Primary

MeasureTime frame
To evaluate and compare the clinical efficacy of scaling and root planing (SRP) alone and in combination with ofloxacin-incorporated and metronidazole-incorporated titanium-prepared platelet-rich fibrin (T-PRF) as adjuncts in non-surgical periodontal therapyTimepoint: Baseline, 1 month, 3 months

Secondary

MeasureTime frame
To compare and analyze the clinical outcomes of SRP alone, SRP with ofloxacin-incorporated T-PRF, and SRP with metronidazole-incorporated T-PRF in non-surgical periodontal therapy Timepoint: Baseline, 1 month, 3 months

Countries

India

Contacts

Public ContactDr Prakash Pai G

KVG Dental College and Hospital

prakashpaipai2014@gmail.com9845156405

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026