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Comparing Eye Nerve Changes in People With and Without High Blood Pressure

A study of the relationship between systemic hypertension and retinal nerve fibre layer/ganglion cell-inner plexiform layer thickness ratio. A comparative analysis.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/11/098008
Enrollment
150
Registered
2025-11-25
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H358- Other specified retinal disorders

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Not applicable

Sponsors

Nerella Satya sri
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Diagnosed systemic hypertension as per JNC criteria Age-matched normotensive controls Eyes without a history of intraocular surgery (except uncomplicated cataract surgery) Grade IV hypertensive retinopathy patients enrolled only if regular ophthalmic examination (fundus photography, OCT) for greater than 6 months Pupil dilatation greater than 6mm Willing to provide informed consent

Exclusion criteria

Exclusion criteria: Patients with uncontrolled BP -systolic BP 140 mmHg or diastolic BP more than 90 mmHg and acute HTNR changes like cotton wool spots, retinal hemorrhages, exudative retinal detachment. Eyes with BCVA less than 0.7, IOP greater than 21mmHg and axial length greater than 26.0mm

Design outcomes

Primary

MeasureTime frame
Difference in the retinal nerve fibre layer/ganglion cell-inner plexiform layer (RNFL/GC-IPL) thickness ratio among (a) hypertensives with retinopathy, (b) hypertensives without retinopathy, and (c) age-matched healthy controls, as measured by spectral-domain OCT.Timepoint: Baseline, 4 weeks, 8 weeks

Secondary

MeasureTime frame
NilTimepoint: Nil

Countries

India

Contacts

Public ContactNerella Satya sri

Alluri sitharamaraju academy of medical sciences

sumakeerthi.dr@gmail.com96769 65664

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026