Health Condition 1: J168- Pneumonia due to other specified infectious organisms
Conditions
Interventions
Intervention1: Oral care with 3% NORMAL SALINE: In Group B (3% normal saline) oral hygiene will be performed using 3% normal saline solutions 10 ml with Respi-clean oral brush. The teeth will be clean
Sponsors
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients more than or equal to 18 years of age; receiving invasive mechanical ventilation (MV) with an expected duration of MV more than 7 days and modified CPIS less than 6 as well as previously admitted patients with endotracheal or tracheostomy with modified CPIS less than 6 for at least 5 days will be recruited in the trial.
Exclusion criteria
Exclusion criteria: Already recruited patients. Patients with diagnosed or suspected VAP on admission, who have undergone intraoral surgery; who denied consent, pregnant patients and patients with known chlorhexidine allergy will be excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compare the incidence of VAP between patients receiving oral care with 0.2% chlorhexidine versus those receiving oral care with 3% normal saline during 14 days period.Timepoint: during 14 days period after initiating oral care. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Compare the effect on colonizers of oral secretions between patients receiving oral care with 0.2% chlorhexidine versus those receiving oral care with 3% normal saline during 14 days period.Timepoint: during 14 days period after initiating oral care;To compare the shift in microbiome in patients with VAP in both groups.Timepoint: during 14 days period after initiating oral care.;Compare the 28 days mortality between the two groups.Timepoint: at 28 days after initiating oral care.;Compare the duration of ventilation free days between the groups.Timepoint: till discharge/death;Compare the change of antibiotic for respiratory cause between the groupsTimepoint: during 14 days period after initiating oral care. | — |
Countries
India
Contacts
Public ContactSangam Yadav
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Outcome results
None listed