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Efficacy and safety of Dexamethasone Cyclophosphamide Pulse Therapy compared with Conventional Oral Corticosteroid Therapy in Pemphigus Vulgaris

Comparative analysis of dexamethasone cyclophosphamide pulse therapy and conventional corticosteroid therapy in pemphigus vulgaris - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/097996
Enrollment
50
Registered
2025-11-24
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L100- Pemphigus vulgaris

Interventions

Intervention1: Comparative Analysis of Dexamethasone Cyclophosphamide Pulse Therapy (DCP)and Conventional Corticosteroid Regime(CCR )in Pemphigus Vulgaris.: In Group A (DCP Therapy) patients were give

Sponsors

Department of Dermatology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: patient age 18 -60 years patient willing to give conscent biopsy proven pemphigus vulgaris

Exclusion criteria

Exclusion criteria: Active infection Immunocompromised Major cardiac, hepatic, renal or Cerebrovascular disease Patients With any other chronic disease

Design outcomes

Primary

MeasureTime frame
pemphigus disease area index (PDAI) score OF 0 for 2 consecutive monthsTimepoint: every 28 days for 1 year—

Secondary

MeasureTime frame
To compare the relapse rate and time for induction of remission Timepoint: at the end of 1 year;To determine the cumulative steroid burden in both groups.Timepoint: at end of 1 year—

Countries

India

Contacts

Public ContactDr.Pratibha Sharma

Mahatma Gandhi Medical College, Jaipur

drpratibhasharma@mgumst.org9928106796

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026