Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Breast conservation surgery (BCS): Breast conservation surgery includes excision of the breast lump, along with 1cm rim of normal tissue all around and reconstruction to achieve accepta
Sponsors
Dr Ephraim Rebba
Eligibility
Inclusion criteria
Inclusion criteria: 1. Breast cancer patients with skin involvement (T4b) who have responded (complete, partial, and stable disease) to NACT (response assessed using the RECIST 1.1 criteria). 2. Patients willing to consent for the study
Exclusion criteria
Exclusion criteria: 1. Progressive disease after NACT 2. Supraclavicular nodes (N3 disease) 3. Fixed axillary nodes 4. Metastatic disease(M1 disease) 5. Poor general conditions with ECOG score of 2 or more precluding NACT or surgery or radiation with a known history of liver .cardiac and renal disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate disease free survival rates of breast conservation and modified radical mastectomy following neoadjuvant chemotherapy in locally advanced breast cancer patients with skin involvementTimepoint: Three years | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate overall survival and ipsilateral breast tumor recurrence rates between the two surgical approachesTimepoint: Three years;To assess postoperative complications (30-day morbidity) using the Clavien-Dindo scoring systemTimepoint: 30 days;To study the pathological outcomes of these patientsTimepoint: 30 days | — |
Countries
India
Contacts
Public ContactDr Ephraim Rebba
AIIMS PATNA
Outcome results
None listed