None listed
Conditions
Interventions
Intervention1: Measurement of GFR using plasma iohexol clearance.: Baseline GFR will be measured using plasma iohexol clearance. Stress GFR will be measured after 7 days by giving oral milk based prot
Sponsors
Department of Nephrology
Eligibility
Inclusion criteria
Inclusion criteria: Age 18 to 50 years Voluntary kidney donor
Exclusion criteria
Exclusion criteria: 1. Subjects with pre-existing comorbidities or history of systemic hypertension, diabetes mellitus, coronary artery disease, chronic obstructive pulmonary disease, renal stone disease or chronic liver disease 2. History of active malignancy or treatment for malignancy in the past 3. Pregnancy, in case of females 4. History of voiding dysfunction 5. Allergy to iohexol or iodinated contrast media 6. Subjects with lactose intolerance or allergy to milk / milk based products
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To measure renal functional reserve using iohexol clearance using protein load in prospective living kidney donors before kidney donationTimepoint: To measure renal functional reserve in prospective living kidney donors and its association with renal function 6 months post kidney donation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) To ascertain association of pre-donation renal functional reserve with measured GFR at 6 months after kidney donation in living kidney donors 2) To ascertain bias between measured GFR & estimated GFR (by CKD-EPICr 2021) at 6 months after kidney donation in living kidney donorsTimepoint: Baseline, day 7 & 6 months post kidney donation | — |
Countries
India
Contacts
Public ContactAmit Ganwani
PGIMER
Outcome results
None listed