Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Dexmedetomidine: 1 microgram per kg of dexmedetomidine in 100 ml of normal saline over 10 minutes before induction of general anaesthesia
Control Intervention1: 0.9% Normal Saline: 0.9%
Sponsors
Rachel B Singh
Eligibility
Inclusion criteria
Inclusion criteria: Patients undergoing elective surgery (defined as a procedure that is not an emergency and can be scheduled in advance) under general anaesthesia. American Society of Anesthesiologists (ASA) I & II.
Exclusion criteria
Exclusion criteria: Any contraindications to general anesthesia. Sensitivity or allergy to any of the study drugs. Pregnancy. Patients with elevated CPK levels pre-operatively polytrauma, Crush injuries. Morbid obesity. Patients on anti-psychotic medication. History of masseter spasm (Malignant Hyperthermia).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dexmedetomidine helps reduce the myalgia caused by succinylcholine administered during induction of general anesthesia.Timepoint: Immediate post operatively and 24 hours post operatively | — |
Secondary
| Measure | Time frame |
|---|---|
| Succinylcholine causes mylagia which can be correlated with rise in creatine phospokinase levels in the serumTimepoint: Immediate Pre-operative and 24 hours post-operative. | — |
Countries
India
Contacts
Public ContactRachel B Singh
Christian Medical College and Hospital Ludhiana
Outcome results
None listed