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Effect of different doses of Magnesium Sulphate for pain relief in old patients after knee replacement

Effect of different doses of Magnesium Sulphate in adductor canal block on postoperative pain in elderly patients undergoing Total knee arthroplasty: a randomized prospective double blind study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/097913
Enrollment
100
Registered
2025-11-24
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M179- Osteoarthritis of knee, unspecified

Interventions

Intervention1: Magnesium Sulphate 250 mg: Magnesium Sulphate 250 mg in addition to 20 ml of .2 % ropivacaine in Adductor canal block once after surgery Intervention2: Magnesium Sulphate 500 mg: Magnes

Sponsors

AIIMS DELHI
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA physical status I III 2. Scheduled for elective unilateral primary TKA 3. Able to understand pain scoring and give informed consent

Exclusion criteria

Exclusion criteria: 1. Allergy to study drugs 2. Chronic opioid use or neuropathic pain 3. Neuromuscular disorders 4. Local infection at injection site 5. Severe hepatic/renal dysfunction or cognitive impairment

Design outcomes

Primary

MeasureTime frame
To compare the time to first breakthrough pain (time to first request for rescue analgesia) in the different doses of Magnesium Sulphate (125 mg, 250 mg, 500 mg, and 1 g) as an adjuvant to ropivacaine in Adductor canal blockTimepoint: 2,4,6,12,24 hours—

Secondary

MeasureTime frame
VAS scores (0 10) at rest and during 45 knee flexion at 2, 6, 12, 24, and 48 hours postoperatively Total opioid consumption 0.5 mg /kg fentanyl in first 48 hours Quadriceps strength using Handheld dynamometer Adverse effects: nausea, vomiting, sedation, hypotension, bradycardia, motor weakness Timepoint: 2,4,6,12,24 hours—

Countries

India

Contacts

Public ContactNeha Garg

All India Institute Of Medical Sciences, Delhi, India

nehagargpgimer@gmail.com09711896795

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026