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Evaluating the Impact of a Vitamin D Receptor Gene Change on Oral Precancer Risk

FokI Vitamin D Receptor Gene Polymorphism and its correlation with precancerous lesions - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/11/097901
Enrollment
400
Registered
2025-11-24
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Nil: Nil

Sponsors

VGST
Lead Sponsor
Nitte Deemed to be University
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Participants with and without precancerous lesions Healthy individuals who are under taking any nutriti onal supplements and are free from systemic diseases.

Exclusion criteria

Exclusion criteria: Subjects with a former positive history of other types of cancer or any type of systemic infections, endocrinological, metabolic, and inflammatory disease. Patients with lipid-lowering drugs, oral antioxidants, or vitamin supplements.

Design outcomes

Primary

MeasureTime frame
To analyse the oral health and its correlation with the rs2228570 single-nucleotide polymorphism in healthy individuals and individuals with precancerous lesions.Timepoint: Baseline—

Secondary

MeasureTime frame
To compare the distribution & frequency of the rs2228570 polymorphism between healthy individuals & those with precancerous lesions.Timepoint: baseline—

Countries

India

Contacts

Public ContactProf Dr Mithra N Hegde

AB Shetty Memorial Institute of Dental Sciences

drmithra.hegde@nitte.edu.in9845284411

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026