Health Condition 1: J984- Other disorders of lung
Conditions
Interventions
Intervention1: NIL: NIL
Intervention2: Nil: Nil
Sponsors
National Institutes of Health NIH
Eligibility
Inclusion criteria
Inclusion criteria: 1 Adults more thab 18 years of age 2 Xpert Ultra PTB -MTB detected and subsequently confirmed by MTB culture 3 Ability and willingness to provide informed consent, including consent for blood and sputum collection and storage for future research
Exclusion criteria
Exclusion criteria: 1 More than 7 days of TB treatment for current TB episode 2 Prior history of TB, regardless of treatment duration 3 Multi- or extensively-drug resistant pulmonary TB, or poly-resistant pulmonary TB 4 Extra-pulmonary TB without microbiologically confirmed pulmonary involvement 5 Prior physician diagnosis of any chronic lung disease or cardiovascular disease 6 Pregnant women or those who plan to get pregnant during the study period 7 Severe illness which, in the study clinician s judgement, will interfere with the participants ability to complete all study visits
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcomes will focus on persistent PTLD and sub-clinical CVD, with secondary outcomes including changes in lung function and cardiovascular parameters. This study aims to fill critical knowledge gaps and establish a valuable resource for future research on post-TB sequelae.Timepoint: 0 week, 6 months and 12months | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes will include changes in lung function, 6 min walk distance, respiratory questionnaire scores, & quantitative imaging parameters. For Aim 2, the primary outcome will be persistent sub-clinical CVD, identified through various cardiovascular assessments. Secondary outcomes will include changes in ejection fraction, carotid intima-media thickness, & pulmonary artery systolic pressure.Timepoint: 0 week, 6 months & 12months | — |
Countries
India, Philippines, South Africa, Uganda
Contacts
Public ContactDevasahayam J Christopher
Christian Medical College, Vellore
Outcome results
None listed