A Clinical Study Comparing Cold Irrigation and Silver Chitosan Irrigation to Standard Techniques to Reduce Pain After Root Canal Treatment.

COMPARATIVE EVALUATION OF CRYOTHERAPY AND SILVER NP CHITOSAN NP IRRIGATION REGIMEN TO STANDARD IRRIGATION REGIMEN IN POST-OPERATIVE PAIN REDUCTION IN THE INDIVIDUALS NEEDING ENDODONTIC TREATMENT : A RANDOMISED DOUBLE-BLINDED CLINICAL TRIAL. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/11/097836

Enrollment

120

Registered

2025-11-21

Start date

Unknown

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K044- Acute apical periodontitis of pulpal origin Health Condition 2: K041- Necrosis of pulp Health Condition 3: K040- Pulpitis

Interventions

Intervention1: Standard Irrigation Regimen @ Cryotherapy Temperatures (StdCr): 5.25% NaoCl at 2.5 C

0.9% Physiologic Saline at 2.5 C

17% EDTA Liquid at 2.5 C Intervention2: AgNP Chitosan NP nanoparticle irrigation regimen @ Room Temperature (NPRt): AgNP Solution at Room temperature

0.9% Physiologic Saline at Room temperature

Nano-Chitosan at Room temperature. Intervention3: AgNP Chitosan NP nanoparticle irrigation regimen @ Cryotherapy Temperatures (NPCr): AgNP Solution at 2 C-4 C.

0.9% Physiologic Saline at 2 C-4 C.

Nano-Chitosan at Room temperature at 2 C-4 C. Control Intervention1: Standard Irrigation Regimen @ Room Temperature (StdRt): 5.25% NaOCl at Room temperature

17% EDTA Liquid at Room temperature

Eligibility

Inclusion criteria

Inclusion criteria: 1. Mature, Permanent Premolar or Molar Teeth requiring endodontic treatment. 2. Pulpal and Periapical Diagnoses 1. Symptomatic irreversible pulpitis (SIP); 2. Symptomatic irreversible pulpitis (SIP) with Symptomatic Apical Periodontitis (SAP); 3. Symptomatic Apical Periodontitis (SAP) without Symptomatic irreversible pulpitis (SIP); 4. Pulpal Necrosis (PN) with Symptomatic Apical Periodontitis (SAP).

Exclusion criteria

Exclusion criteria: 1. Morbid Individuals with Systemic Diseases. 2. Individuals in gestational or lactation period. 3. Aberrant root canal anatomies. 4. Pulp Space Calcifications. 5. Badly Broken-down teeth. 6. Secondary endodontic infection 7. Periodontally compromised teeth. 8. Rubber dam isolation not possible.

Design outcomes

Primary

Measure	Time frame
Post-operative pain on Visual Analogue Scale (VAS)Timepoint: Immediate Post-Op, at 6 hours, 12 hours, 24 hours, 72 hours and 1 week.	—

Secondary

Measure	Time frame
post operative painTimepoint: one week postoperatively	—

Countries

India

Contacts

Public ContactDr Sarathi Vin

T.P.C.Ts Terna Dental College and Hospital

sarathi.vin@gmail.com9819503785

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026