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Low-Level Laser Therapy vs Intracanal Cryotherapy: Managing Pain After Single Visit Root Canal Treatment in Lower Molars

Comparing the Effect of Low Level Laser Therapy and Intracanal Cryotherapy on Post Operative Pain following Single-Visit Nonsurgical Endodontic Treatment of Mandibular Molars with Irreversible Pulpitis and Apical Periodontitis a Randomized Clinical Trial - NIL

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/097786
Enrollment
75
Registered
2025-11-20
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: K040- Pulpitis

Interventions

Intervention1: Low Level Laser Therpay: 1) To evaluate the degree of post-operative pain following single-visit root canal treatment of mandibular molars with irreversible pulpitis and/or apical perio

Sponsors

Manali Jagtap
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients requiring root canal treatment of mandibular 1st and 2nd molars 2. Patients diagnosed with irreversible pulpitis and or apical periodontitis 3. Teeth with spontaneous pain or lingered by cold or heat 4. Teeth with mature apex 5. Teeth with mobility less than 1mm in either direction 6. PAI Index score of 2 or 3 7. Pre operative tooth and percussion pain of less than 56 mm on a 170 mm visual analogue scale

Exclusion criteria

Exclusion criteria: 1. Medically compromised patients (history of pregnancy, malignancy, diabetes mellitus) 2. Patients with other pulpal diagnosis 3. Patients with a history of analgesic intake (antibiotics, NSAIDs, opioids or corticosteroids) during 12 hours prior to treatment 4. Presence of complex anatomy of the root (severe curvature more than 25 degrees) 5. Calcified or obstructed canals on radiographs 6. Very long roots 7. Internal or External root resorption 8. Teeth with open apex 9. Teeth with procedural errors 10. Presence of any defect in the root such as caries, restoration, previously endodontically treated, root resorption, craze lines and fracture 11. Severely damaged teeth 12. Teeth with severe periodontal disease 13. Teeth with periodontal probing depth more than 3 mm 14. Teeth associated with swelling, sinus tract, presence of a radiographic lesion 15. Tooth hypersensitivity to percussion 16. Absence of occlusal contact 17. Absence of palpation sensitivity

Design outcomes

Primary

MeasureTime frame
1)To evaluate the degree of post-operative pain following single-visit root canal treatment of mandibular molars with irreversible pulpitis and/or apical periodontitis in conjunction with Low-level Laser Therapy. 2)To evaluate the degree of post-operative pain following single-visit root canal treatment of mandibular molars with irreversible pulpitis and/or apical periodontitis in conjunction with Intracanal Cryotherapy Timepoint: Baseline T0 6 hours T1 12 hours T2 24 hours T3 48 hours T4 72 hours T5

Secondary

MeasureTime frame
3) To compare and evaluate the reduction in the degree of post-operative pain following single-visit root canal treatment of mandibular molars with irreversible pulpitis and/or apical periodontitis between Low-level Laser Therapy and Intracanal CryotherapyTimepoint: Baseline T0 6 hours T1 12 hours T2 24 hours T3 48 hours T4 72 hours T5

Countries

India

Contacts

Public ContactManali Jagtap

Manubhai Patel Dental College and Hospital

aroraankit24@gmail.com9033975629

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026