Comparing Platelet-Rich Plasma and Placentrex with Hyaluronidase Injections for Better Healing After Surgery in Oral Submucous Fibrosis : A Clinical Study

A Comparative Evaluation of the Efficacy of Submucosal Injections of Autologous Platelet-Rich Plasma Versus Placentrex Combined with Hyaluronidase in the Management of Oral Submucous Fibrosis Following Immediate Surgical Release of Fibrous Bands: A Randomized Controlled Clinical Trial. - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/11/097772

Enrollment

Registered

2025-11-20

Start date

Unknown

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z128- Encounter for screening for malignant neoplasm of other sites

Interventions

Intervention1: Autologous Platelet Rich Plasma: Autologous platelet Rich plasma is derived from patients own blood. 2ml of platelet rich plasma will be injected intraoperatively and follow up will be

Eligibility

Inclusion criteria

Inclusion criteria: Patients of Stage IV OSMF according to Khanna and Andrade classification (1995)30. Patients in age group 20-50 years. Patient willing for cessation of habit

Exclusion criteria

Exclusion criteria: Temporomandibular joint disorder or trauma to it. Patient giving history of allergy to placentrex injection . Clinical signs and symptoms or proven report of malignancy and red and white lesion.

Design outcomes

Primary

Measure	Time frame
To evaluate and compare the efficacy of autologous platelet-rich plasma and Placentrex in combination with hyaluronidase for improving mouth opening in oral submucous fibrosis following immediate surgical release of fibrous bands for 3 months.Timepoint: 3 months	—

Secondary

Measure	Time frame
To evaluate and compare the efficacy of autologous platelet-rich plasma and Placentrex in combination with hyaluronidase for reducing burning sensation and increasing cheek flexibility in oral submucous fibrosis following immediate surgical release of fibrous bands for 3 months.Timepoint: 3 months	—

Countries

India

Contacts

Public ContactDr Deepali Surti

Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital

mayur.gawande@sdk-dentalcollege.edu.in8793851956

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026