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Comparison of 0.25% Bupivacaine versus 0.25% Bupivacaine with Dexmedetomidine in Ultrasound guided Adductor canal Block for post-operative pain relief after total knee replacement: A Randomized controlled Study

Comparision of 0.25% Bupivacaine Vs 0.25% Bupivacaine and 0.5mcg/kg Dexmedetomidine in USG-guided Adductor Canal Block for Post-operative Pain Relief after Knee Replacement Surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/097771
Enrollment
120
Registered
2025-11-20
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Drug: 0.25% Bupivacaine with Dexmedetomidine : Patients will receive an ultrasound-guided Adductor Canal Block (ACB) with 20 ml of 0.25% Bupivacaine + 0.5 mcg/kg Dexmedetomidine, admin

Sponsors

Command Hospital Airforce Bangalore
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA Physical Status I-III Scheduled for Unilateral elective total knee replacement

Exclusion criteria

Exclusion criteria: Allergy to Bupivacaine or Dexmedetomidine Pre-existing neurological/neuromuscular disorders Coagulopathy or on anticoagulants Severe cardiovascular disease Bilateral total knee replacement Unicondylar knee replacement

Design outcomes

Primary

MeasureTime frame
To compare postoperative pain relief using VAS scores at 2, 6, 12, and 24 hours.Timepoint: To compare postoperative pain relief using VAS scores at 2, 6, 12, and 24 hours.—

Secondary

MeasureTime frame
Duration of analgesia (from block to first rescue analgesia) Patient satisfaction score. Hemodynamic parameters Incidence of adverse effects (hypotension, bradycardia, motor blockade, urinary retention,sedation, nausea, vomiting)Timepoint: ;Time to first rescue analgesia Total opioid consumption in 24 hours VAS pain scores at rest & movement at predetermined intervals Hemodynamic parameters HR MAP Adverse events nausea vomiting bradycardia hypotension sedation block-related complicationsTimepoint: At 4 8 12 24 hours—

Countries

India

Contacts

Public ContactDr Avanish Bhardwaj

Command hospital Airforce

Avanishbhardwaj78@gmail.com9914734466

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026