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A study to observe occurrence of abnormally increased pain sensation to morphine in the preoperative period

Evaluation for the occurrence of preoperative morphine induced acute hyperalgesia at sequential doses using Algesiometer and Surgical Pleth Index - A Prospective observational Study. - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/097738
Enrollment
84
Registered
2025-11-20
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: morphine: evaluate for occurrence of morphine induced acute hyperalgesia Intervention2: Nil: Nil

Sponsors

PADAVALA SAI ALEKHYA
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Scheduled for elective surgeries under general anesthesia Receiving morphine a premedication Provide informed consent for participation

Exclusion criteria

Exclusion criteria: History of chronic opioid use or dependence Neuropathic pain disorders or chronic pain syndromes Hepatic or renal dysfunction Known allergy to opioids Patients on antidepressants, anticonvulsants, or analgesics preoperatively Refusal to participate

Design outcomes

Primary

MeasureTime frame
Change in pain threshold measured by Algesiometer and change in Surgical Pleth Index (SPI) values before and after preoperative intravenous morphine administration to detect morphine-induced acute hyperalgesia.Timepoint: Baseline,at 2.5 minutes,5 minutes—

Secondary

MeasureTime frame
Correlation between morphine dose & degree of hyperalgesia Hemodynamic response (HR, MAP) after morphine Timepoint: Baseline,at 2.5 minutes, 5 minutes—

Countries

India

Contacts

Public ContactPADAVALA SAI ALEKHYA

nizams institute of medical sciences

kirankumaranne@yahoo.com9052709777

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026