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Assessing Muscle Recovery After Anaesthesia: Train-of-Four vs Diaphragm Ultrasound

Accuracy of train of four ratio and ultrasound derived diaphragm excursion as an indicator of reversal of neuromuscular blockade - NIL

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/11/097736
Enrollment
90
Registered
2025-11-20
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Nil: Nil

Sponsors

Harman Preet Singh Kalra
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients posted for elective surgeries under general anaesthesia. 2.ASA grades I and II.

Exclusion criteria

Exclusion criteria: 1.Surgical procedures performed in critical or urgent situations. 2.Patients with pre existing pulmonary diseases. 3.Patients with phrenic nerve paralysis. 4.Patients with Neuromuscular disorders such as Myasthenia Gravis etc.

Design outcomes

Primary

MeasureTime frame
To determine accuracy of train of four ratio and ultrasound derived diaphragm excursion as an indicator of reversal of neuromuscular blockade.Timepoint: The TOF will be calculated at the baseline before induction and before extubation when spontaneous respiration returns. The diaphragm excursion will be measured as the vertical movement of the right hemidiaphragm during quiet spontaneous breathing, before the induction of the patient and before extubation, on return of spontaneous respiration and in the post operative room at different times (15 mins, 30 mins, 45 mins).

Secondary

MeasureTime frame
1.To assess reversal of neuromuscular blockade at the end of surgery by these two methods 2.To determine the prevalence of postoperative respiratory complications (PORC) if any in the immediate postoperative period. 3.To observe for any persistence of NM blockade after use of neostigmine in patients by measuring the diaphragmatic excursion at baseline, prior to extubation of the patient, at 10 mins in the PACU, at 15 mins & at 30 mins in the PACU. Timepoint: Diaphragmatic Excursion to be measured at baseline, prior to the extubation, at 10 mins in the PACU, at 15 mins in the PACU & at 30 mins in the PACU.

Countries

India

Contacts

Public ContactHarman Preet Singh Kalra

Rohilkhand Medical College and Hospital, Bareilly

pathaniajyoti7@gmail.com9418120659

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026