Health Condition 1: N200- Calculus of kidney Health Condition 2: N202- Calculus of kidney with calculus of ureter Health Condition 3: N201- Calculus of ureter
Conditions
Interventions
Intervention1: Nebulized Ketamine: Ketamine 1mg/kg given over 15 mins and reassess after every 15 mins for 1 hour
Control Intervention1: Intravenous Lornoxicam: IV Lornoxicam 8mg Infusion over 15 min
Sponsors
Department of Emergency Medicine
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients of age 18-65 years presenting with acute renal colic pain to the Emergency Department 2.Confirmed or highly suspected renal colic diagnosis (based on clinical presentation with or without imaging). 3.Pain score less than or equal to 5 on a 0 to 10 numerical rating scale 4.Warranted use of ketamine or NSAIDs as determined by treating physician 5.Patients had to be awake, alert, and oriented to person, place, and time
Exclusion criteria
Exclusion criteria: 1.Imaging or Investigations indicating no renal or ureteric calculi 2.Known hypersensitivity to Ketamine or IV NSAIDS 3.Patients who received analgesics within 4 hours prior to ED arrival 4.Conditions where ketamine or NSAIDs are contraindicated GI bleeding, AKI, CKD, Psychosis, CAD, CLD 5.Unstable vital signs (SBP less than 90 mm Hg or more than 180 mm Hg, Pulse less than 50 bpm or more than 150 bpm, or RR less than 10 or more than 30 bpm) 6.Conditions where peritoneal inflammation is suspected 7.Patients who are pregnant or breastfeeding 8.Patients with altered mental status and unable to give consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare pain reduction after administration of nebulized Ketamine with that of intravenous Lornoxicam in patients with renal colic, measured using Numerical Rating ScaleTimepoint: 15, 30, 45 and 60 minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| To observe time to significant pain relief (NRS fall more than or equal to 3)Timepoint: Reassessed at 15, 30, 45 and 60 minutes;To assess the need for rescue analgesia using a strong opioid (IV Fentanyl)Timepoint: Assessed at 15, 30, 45 and 60 minutes;To study acute adverse effect profile of both drugsTimepoint: ;To assess the level of Patient satisfaction (using 5 point Likert scale)Timepoint: | — |
Countries
India
Contacts
Public ContactDr. Nisanth Menon N
Malankara Orthodox Syrian Church Medical College Hospital
Outcome results
None listed