Health Condition 1: J99- Respiratory disorders in diseasesclassified elsewhere
Conditions
Interventions
Intervention1: Nebulised Salbutamol: 0.15mg/kg/dose with 3ml NS with 6-8l O2 over 15-20mins
Intervention2: Nil: Nil
Control Intervention1: Normal saline: 0.15mg/kg/dose with 3ml NS with 6-8l O2 over 1
Sponsors
ICMR PG THESIS FUND
Eligibility
Inclusion criteria
Inclusion criteria: 1. Term neonates greater than 37 weeks gestation) 2.Age less than 6 hours 3.Clinical and radiological findings suggestive of TTNB as per Rawlings and smith which is based on the radiologic and clinical findings Clinically: 1. Early (within 6 hours of birth) onset of tachypnea 2. Persistence of tachypnea sometimes with retractions, or expiratory grunting and, occasionally, cyanosis that is relieved by minimal oxygen supplementation. 3. Chest generally sounds clear without rales or rhonchi. Chest radiograph shows: a. Prominent pulmonary vascular markings. b. Fluid in the interlobar fissure. c. Flat diaphragms and rarely pleural effusion. d. Hyperaeration 4. Term Neonates diagnosed with TTNB whose parents are willing for consent
Exclusion criteria
Exclusion criteria: 1.Preterm neonates less than 37 weeks of gestation 2.Major congenital anomalies of lung and heart 3.Perinatal asphyxia (Apgar less than 5 at 5 min) 4.Sepsis (Sepsis screening or culture-positive) 5.Meconium aspiration syndrome or other diagnosed cause of respiratory distress 6.Term Neonates diagnosed with TTNB whose parents are not willing for consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We anticipate that Nebulized Salbutamol will significantly reduce the time taken to resolve TTN in term neonates and accelerate clinical improvement, thereby facilitating earlier discharge and decreasing NICU burden. Timepoint: At 24 hrs, 48 hrs and 72 hrs | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Need for mechanical ventilation 2. Duration of NICU stay 3. Adverse effects Timepoint: At 24 hrs, 48hrs & 72 hrs | — |
Countries
India
Contacts
Public ContactDr G Harinie
Trichy SRM Medical College Hospital And Research Center
Outcome results
None listed