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A study in dental patients to find out whether changing the temperature of a numbing medicine (lignocaine) reduces injection pain and improves the numbing effect

Does temperature modulation of 2 percent lignocaine influence injection pain and anaesthetic efficacy? A comparative clinical study with objective and subjective pain metrics - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/097664
Enrollment
69
Registered
2025-11-18
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: 2% lignocaine at body temperature: 2% lignocaine at body temperature i.e. 37 degrees centigrade will be given to the respective branches of maxillary or mandibular nerves depending on

Sponsors

Dr Medithi Jahnavi Priya
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Indicated for premolar extraction (orthodontic need) OR third molar extraction. 2.Able to give written informed consent (or parent/guardian consent for minors if included). 3.No analgesics or sedatives in prior 48 hours.

Exclusion criteria

Exclusion criteria: 1.Allergy to amide local anesthetics (lignocaine), or sulfites 2.Active infection/abscess at injection site (would alter pain/anesthesia). 3.Chronic pain syndromes, neuropathies, psychiatric illness altering pain reporting. 4.Pregnancy/lactation. 5.Prior local anesthetic within 24 hours in same area. 6.Inability to understand or use the pain scales.

Design outcomes

Primary

MeasureTime frame
Pain during injection will be recorded using by Visual Analog Scale immediately after injectionTimepoint: 0min, 1min, 2min

Secondary

MeasureTime frame
Objective behaviour response during injectionTimepoint: 0 min;Duration of anaesthesiaTimepoint: 30 min, 45 min, 60 min, 75 min, 90 min,105 min, 120 min;Onset of anesthesiaTimepoint: 0 sec, 30 sec, 60 sec,90 sec,120 sec, 150sec,180,210 sec,240 sec, 270 sec,300 sec;Adverse events Timepoint: 1 day, 2nd day, 3rd day

Countries

India

Contacts

Public ContactDr Ponamandi Nagalakshmi

Vishnu Dental College

pnagalakshmi7799@gmail.com8179773004

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026