Health Condition 1: V892- Person injured in unspecified motor-vehicle accident, traffic
Conditions
Interventions
Intervention1: Adding drug to compare if there is any change in the outcome of traumatic brain injury patients: Tab Atorvastatin 20mg P/O OD for 10 days
Control Intervention1: Standard of Care: All pa
Sponsors
AIIMS PATNA
SHAMAN SINGH
Eligibility
Inclusion criteria
Inclusion criteria: 1. Isolated TBI 2. GCS-3-12
Exclusion criteria
Exclusion criteria: 1. Polytrauma with life threatening Extracranial injuries. 2. Pre existing statin therapy or contraindications to statins (e.g., hepatic dysfunction, myopathy). 3 Severe hepatic or renal impairment. 4 Pregnancy or lactation. 5 Patients with penetrating head injuries or prior neurosurgical interventions. 6 Patients or guardians unwilling to participate. 7 Patients requiring surgical intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To compare the rate of reduction in contusion volume in TBI patients with statin therapy vs placebo 2. To assess and compare the rates of improvement in GOS-E and DRS in patients with statins vs placebo 3. To evaluate and compare the duration of in-hospital stay in patients receiving statins vs placebo Timepoint: 1. At 1,3,7 and 10 days 2. At 4 weeks and 9 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactShaman Singh
AIIMS PATNA
Outcome results
None listed