Health Condition 1: J00-J99- Diseases of the respiratory system
Conditions
Interventions
Intervention1: Analgesia based sedation using Dexmedetomidine: Intubated and Mechanically ventilated patients in ICU will receive intravenous Dexmedetomidine infusion at 0.2-0.7 mcg/kg/hours for durat
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years 2. Admitted to the ICU within 24 hours of intubation and mechanical ventilation 3. Intubated in ICU
Exclusion criteria
Exclusion criteria: 1. Patient receiving other sedative analgesic drugs (Benzodiazepine, Propofol) 2. Life-threatening bleeding, the presence of hemorrhagic shock, as judged by research or treating clinicians 3. Burns, Pregnancy 4. Referral from or treated at other healthcare facilities 5. Withdrawal of consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare concentration changes in Oxyhemoglobin at somatosensory cortex during nociceptive stimuli (endotracheal suctioning) in mechanically ventilated patients in intensive care unit receiving either dexmedetomidine of fentanyl for analgesia-based sedation.Timepoint: Day 1 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Assess the association of changes in Oxyhemoglobin concentration in somatosensory cortex with heart rate & blood pressure in response to nociceptive stimuli 2. Assess the association of changes in Oxyhemoglobin concentration in somatosensory cortex with Critical Care Pain Observation Tool in response to nociceptive stimuliTimepoint: Day 1 | — |
Countries
India
Contacts
Public ContactDr. Puneet Khanna
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed