Comparison of Gabapentin, Melatonin, and Clonidine in Reducing Blood Pressure and Heart Rate Changes During Intubation in Treated Hypertensive Patients

A comparative study of effect of pre-treatment with oral Gabapentin versus Melatonin versus Clonidine on hemodynamic response to laryngoscopy and tracheal intubation in controlled hypertensive patients: A double-blinded, randomized controlled study. - Nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/11/097597

Enrollment

108

Registered

2025-11-18

Start date

Unknown

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I10- Essential (primary) hypertension Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Premedication with Oral Clonidine: Controlled hypertensive patients on medication posted for elective surgeries under General Anesthesia will receive Tablet Clonidine 100mcg orally one

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients aged between 18 and 60 years 2. Patients giving written informed consent 3. Controlled hypertensive patients on treatment with BP less than 130/80mmHg 4. ASA grade II patients 5. Patients undergoing elective surgery under General anaesthesia

Exclusion criteria

Exclusion criteria: 1. Patients taking Gabapentin, Melatonin or Clonidine 2. Patients having anticipated difficult airway 3. Patients with other coexisting diseases like Diabetes, Ischemic heart disease, Renal or Hepatic disorders, Arrhythmias. 3. Body Mass Index greater than 25 kg/m 4. Patients on Beta blockers

Design outcomes

Primary

Measure	Time frame
To determine which of the following drugs, Gabapentin, Melatonin or Clonidine will blunt the hemodynamic changes caused during laryngoscopy and intubation better in treated hypertensive patients.Timepoint: 1. Baseline vitals prior to induction of anesthesia 2. Vitals during laryngoscopy and tracheal intubation 3. Vitals 1,2,3,4,5,10,15 minutes after intubation	—

Secondary

Measure	Time frame
To determine the Visual Analogue Scale for anxiety (VAS-A) of the patientsTimepoint: 1. VAS-A prior to administration of premedication 2. VAS-A prior to induction of anesthesia	—

Countries

India

Contacts

Public ContactDr Pradeep Khobragade

AIIMS Raipur

drpradeepk1117@gmail.com9820961117

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026