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Pain control in adults undergoing knee replacement using two types of local anaesthetic injections with clonidine.

Comparative Study Of Ropivacaine Vs Levobupivacaine With Clonidine In Ultrasound Guided Adductor Canal Block For Postoperative Analgesia In Total Knee Arthroplasty - Nil

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/097507
Enrollment
80
Registered
2025-11-17
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M179- Osteoarthritis of knee, unspecified

Interventions

Intervention1: Ropivacaine: Participants will receive 20 mL of 0.25% ropivacaine combined with clonidine (1 mcg/kg) administered as a single-shot, ultrasound-guided adductor canal block (ACB) preopera

Sponsors

Guru Gobind Singh Medical College Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged between 40 to 75 years of either gender giving written willingness consent. Patient belonging to American Society of Anaesthesiology class 1 and 2 and scheduled for elective orthopedic Total knee arthroplasty surgeries under spinal Anaesthesia.

Exclusion criteria

Exclusion criteria: Patients having history of coagulation abnormalities chronic kidney diseases chronic liver diseases Any history of allergy or contraindication to study drugs Any contraindication for neuroaxial anaesthesia

Design outcomes

Primary

MeasureTime frame
Duration of postoperative analgesia, measured as the time from completion of the ultrasound-guided adductor canal block to the first request for rescue analgesia ( assessed using NRS pain score)Timepoint: Immediately after adductor canal block

Secondary

MeasureTime frame
Postoperative pain scores at rest & on movement using the Numerical Rating Scale (NRS) at 0,2,4,6,8,12, & 24 hours. Total rescue analgesia consumption in the first 24 hours postoperatively Incidence of adverse events ( nausea, vomiting, hypotension, bradycardia, block-related complications). Patient satisfaction score at 24 hours post-block. Timepoint: After every 2hour till 24 hours

Countries

India

Contacts

Public ContactDr Sarvjeet Kaur

Guru Gobind Singh Medical College Hospital

drsarvjeetk@gmail.com9915680508

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026