Comparing intravenous Clonidine and Intravenous Magnesium sulphate in decreasing hemodynamic response to laryngoscopy and intubation.

A comparative study between intravenous Clonidine and intravenous Magnesium sulphate in attenuating hemodynamic response to laryngoscopy and intubation a randomised study. - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/11/097503

Enrollment

Registered

2025-11-17

Start date

Unknown

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I10- Essential (primary) hypertension

Interventions

Intervention1: Inj. Clonidine 1mcg/kg in 100 ml NS IV will be given to Group C over 10 mins and inj. Magnesium sulphate 30mg/kg in 100 ml NS over 10 mins will be given to group M.: Intravenous drug wi

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status 1 and 2. Patients undergoing elective surgeries under GA. Patients with BMI less than 30kg/m2 Patients consenting for study

Exclusion criteria

Exclusion criteria: Patients with anticipated difficult airway Pregnant and lactating women Patient allergic to study drugs

Design outcomes

Primary

Measure	Time frame
To determine the effectiveness of intravenous Clonidine versus intravenous Magnesium sulphate in attenuating the hemodynamic response to laryngoscopy and intubation in patients undergoing surgeries under general anaesthesia. To determine which of the two drugs have less side effectsTimepoint: Intraoperatively drug will be administered and hemodynamic responses will be recorded before giving drug, immediately after giving drug, just before induction, after induction followed by 1min, 3 min, 5min and 10 min after intubation. Any adverse effects during study will be noted intraoperatively.	—

Measure

Time frame

To determine the effectiveness of intravenous Clonidine versus intravenous Magnesium sulphate in attenuating the hemodynamic response to laryngoscopy and intubation in patients undergoing surgeries under general anaesthesia. To determine which of the two drugs have less side effectsTimepoint: Intraoperatively drug will be administered and hemodynamic responses will be recorded before giving drug, immediately after giving drug, just before induction, after induction followed by 1min, 3 min, 5min and 10 min after intubation. Any adverse effects during study will be noted intraoperatively.

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Secondary

Measure	Time frame
nilTimepoint: nil	—

Countries

India

Contacts

Public ContactDr Shreyavathi R

Sapthagiri Institute of Medical Sciences and Research Centre

shreyamurthy8993@gmail.com9880588325

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026