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Comparison of remifentanil-based total intravenous anaesthesia and balanced anaesthesia in preventing emergence agitation in patients undergoing nasal surgeries

A comparative study To evaluate the effect of remifentanil based TIVA versus balanced anaesthesia on emergence agitation in patients undergoing nasal surgeries. - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/097500
Enrollment
80
Registered
2025-11-17
Start date
Unknown
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J324- Chronic pansinusitis Health Condition 2: J330- Polyp of nasal cavity Health Condition 3: J342- Deviated nasal septum Health Condition 4: J343- Hypertrophy of nasal turbinates

Interventions

Intervention1: Remifentanil based TIVA: Remifentanil infusion will be started at 0.5mcg/kg/min during induction with TCI device using Schneider model with Inj. Propofol 1% and continued throughout the

Sponsors

MS Ramaiah Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adult patient Aged 18-65 years. 2. Patients scheduled for elective nasal surgeries requiring GA. 3. ASA physical status 1 - 3.

Exclusion criteria

Exclusion criteria: 1. Patients with known allergies to remifentanil or propofol. 2. History of severe cardiovascular, hepatic, or renal diseases. 3. History of substance abuse, including alcohol,or narcotics. 4. Pregnancy or breastfeeding. 5. Patients with a history of significant psychiatric conditions including severe agitation, anxiety disorders or any other conditions leading to increased risk of agitation. 6. Emergency surgery cases.

Design outcomes

Primary

MeasureTime frame
To determine the incidence of emergence agitation in remifentanil based TIVA group and Balanced Anaesthesia group based on RASS score.Timepoint: Emergence agitation will be measured 2 minutes after extubation.—

Secondary

MeasureTime frame
Recovery time T0-T1.Timepoint: Time from discontinuation of all anaesthetic agents to time taken by patient to open eyes to verbal commands.;Time to extubation T1-T2.Timepoint: Time from patient able to open eyes to verbal commands to extubation.;Post-operative pain using NRS.Timepoint: Immediately after arrival to post anaesthesia care unit ,30 min after arrival,60min after arrival .;Post-operative complications like post-operative nausea & vomiting, disorientation & shivering.Timepoint: Immediately after arrival to post anaesthesia care unit,30 min after arrival,60min after arrival.—

Countries

India

Contacts

Public ContactDr Archana S

MS Ramaiah Medical College.

archvinddoc@yahoo.co.in9845121444

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026