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Predicting lung problems in Brain injured patients. A pilot study of non-invasive lung assessment tools in NeuroCritical care

Evaluation of Thoracic Fluid Content and Lung Ultrasound Score in Acute Brain Injury Patients with or without Lung Injury: A Prospective Pilot Observational Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/11/097447
Enrollment
30
Registered
2025-11-14
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S069- Unspecified intracranial injury

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil

Sponsors

National Institute of Mental Health and Neurosciences NIMHANS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All Acute Brain Injury patients admitted to ICU and who are Initiated on invasive mechanical ventilation within 48 hrs of injury to brain and expected to be maintained for at least 48 hours.

Exclusion criteria

Exclusion criteria: 1.Refusal of consent 2.Preexisting known cardiac illness, renal disease (serum creatinine more than 1.5 mg/dl) 3.Any pre-existing lung pathologies or injuries like rib fractures with contusion, or initial blood gasses (done within 6 hours of NICU admission) showing PaO2/FiO2 less than 200. 4.Intubated and referred to from other hospitals. 5.Pregnant women

Design outcomes

Primary

MeasureTime frame
To compare the trends of Thoracic fluid content(TFC) and Lung ultrasound score(LUS) in Acute brain injury(ABI) with or without lung injury (PaO2/FiO2 less than 300) during the first weekTimepoint: Day_0,Day_1,Day_2,Day_3,Day_4,Day_5,Day_6,Day_7—

Secondary

MeasureTime frame
To examine the correlation between TFC and LUS during the first week Timepoint: Day_0,Day_1,Day_2,Day_3,Day_4,Day_5,Day_6,Day_7;To evaluate the predictive value of daily TFC and LUS measurements for the occurrence of ventilator-associated pneumonia (VAP) in mechanically ventilated ABI patients during the first weekTimepoint: Day_0,Day_1,Day_2,Day_3,Day_4,Day_5,Day_6,Day_7;To investigate the association between changes in lung compliance and daily variations in TFC and LUS during the first weekTimepoint: Day_0,Day_1,Day_2,Day_3,Day_4,Day_5,Day_6,Day_7;To find out if the dynamic correlation coefficient between cardiac index (CI) and TFC predicts the development of lung injuriesTimepoint: Day_0,Day_1,Day_2,Day_3,Day_4,Day_5,Day_6,Day_7—

Countries

India

Contacts

Public ContactDr Praveen T

National Institute of Mental Health and Neurosciences(NIMHANS)

litu86@gmail.com9968961339

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026