Health Condition 1: J869- Pyothorax without fistula
Conditions
Interventions
Intervention1: Intrapleural Streptokinase: Intrapleural streptokinase administered as adjunct to conventional management .
Dose - 15000 IU /kg diluted in 50 ml normal saline for 3 days
Control Interv
Sponsors
Shubham Rastogi
Eligibility
Inclusion criteria
Inclusion criteria: Patients with definitive diagnosis of empyema with visible puson diagnostic pleural tap and/or septations /loculations on ultrasound of chest.
Exclusion criteria
Exclusion criteria: a. Any history of coagulopathy b. Confirmed case of pneumothorax or bronchopleural fistula c. Any history of head trauma in preceeding 2 weeks . d. Any history of recent major surgery .
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in pleural fluid volume and improvement in clinical condition (resolution of fever , respiratory distress , and radiological clearance on chest x ray ).Timepoint: Day 7 and at completion of hospital stay. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of hospital stay .Timepoint: 4 weeks;Duration of chest tube drainageTimepoint: 3 weeks.;Requirement of surgical intervention ( decortication )Timepoint: 4 weeks.;Adverse effects or complications related to streptokinaseTimepoint: 4 weeks | — |
Countries
India
Contacts
Public ContactDr Srikanta Basu
Lady hardinge medical college
Outcome results
None listed