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A comparative study of post procedural pain relief of lignocaine spray and EMLA cream during knee injection with corticosteroid

A Comparative Study of the anaesthetic effect of 10 percentage Lignocaine Spray and Eutectic Mixture Of 2.5 percentage Lidocaine and 2.5 percentage Prilocaine (EMLA) Cream During Intra-Articular Corticosteroid Injection of the Knee Joint in patients with Rheumatoid Arthritis - Nil

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/11/097388
Enrollment
120
Registered
2025-11-13
Start date
Unknown
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M069- Rheumatoid arthritis, unspecified

Interventions

Intervention1: Lignocaine spray: 10% spray, applied 3 times, contact time of 20 minutes Intervention2: EMLA Cream: 2.5 grams cream, contact time of 1 hour Intervention3: Nil: Nil Control Intervention1

Sponsors

DR A P NIRMAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Diagnosed case of Rheumatoid Arthritis as per 2010 ACR/EULAR Classification Criteria 2. Having knee joint effusion and requires intra articular corticosteroid injection as per assessment of the treating physician.

Exclusion criteria

Exclusion criteria: 1. Patients with suspicion of septic arthritis 2. History of adverse reactions to lidocaine 3. Superficial skin infection at the injection site 4. Patients with cognitive dysfunction or inability to assess pain scores associated with the procedure. 5. Pregnant and lactating females 6. Joint prosthesis, intra-articular fracture

Design outcomes

Primary

MeasureTime frame
To compare the immediate post-procedural anaesthetic effect of 10% lignocaine spray and EMLA cream in facilitating analgesia during the intraarticular corticosteroid injection in a single knee joint.Timepoint: immediately after giving knee injection—

Secondary

MeasureTime frame
To compare anaesthetic effect of 10% Lignocaine spray and EMLA cream at 1 hour & 24 hour after procedureTimepoint: At 1 hour and 24 hours after procedure;To compare the change in baseline pain scores immediately after IACI.Timepoint:—

Countries

India

Contacts

Public ContactDR YOGESH PREET SINGH

AIIMS BILASPUR

yogeshmann@gmail.com9741592091

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026