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Comparison of 3 medicines dexemedetomidine, nitroglycerin and esmolol- used to control blood pressure and improve the visibility of surgical area in patients undergoing sinus surgery under general anaesthesia

Comparative evaluation of nitroglycerin, esmolol and dexemedetomidine on surgical field condition in patients undergoing functional endoscopic sinus surgery with controlled hypotension under general anaesthesia: An open label and randomized study - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/097375
Enrollment
120
Registered
2025-11-13
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H952- Intraoperative hemorrhage and hematoma of ear and mastoid process complicating a procedure

Interventions

Intervention1: controlled hypotension using any one of dexemedetomidine, nitroglycerin, esmolol: In this study we will use controlled hypotension with target mean arterial blood pressure 60-70 mmHg, d

Sponsors

Sir Ganga Ram hospital, New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 18 -60 years 2. Males and females 3. ASA I or II

Exclusion criteria

Exclusion criteria: 1. Failure to obtain consent 2. Patients with known cardiovascular, renal or hepatic dysfunction 3. Allergic to study drugs 4. Pregnancy or lactation 5. On treatment with beta blockers 6. Anaemia with baseline hemoglobin less than 8g per dl 7. Mean arteial blood pressure less than 70 mmHg at baseline

Design outcomes

Primary

MeasureTime frame
To compare the proportion of patients achieving satisfactoy surgical field, who are recieving either of dexemedetomidine, nitroglycerin or esmolol for controlled hypotension in functional endoscopic sinus surgery under general anaestesiaTimepoint: After start of surgery surgical field score will be assessed by surgeon every 15 minutes till the end of surgery.—

Secondary

MeasureTime frame
To compare among 3 groups: 1. Amount of intraoperative blood loss 2. Hemodynamic profile( mean arterial blood pressure, heart rate) 3. Incidence of hypotension, bradycardia, postopererative nausea and vomiting and postoperative sedation Timepoint: intraoperative period and post operative period of one hour—

Countries

India

Contacts

Public ContactDr Princy Singla

Sir Ganga Ram hospital , New Delhi

savitarmalhotra@yahoo.com9958908713

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026