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Study to see if a special blood product(T-PRF) helps to improve gum health after deep cleaning for gum disease patient

Titanium-Prepared Platelet Rich Fibrin on Non-Surgical Periodontal Therapy: A Split-Mouth Randomized Controlled Clinical Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/097369
Enrollment
24
Registered
2025-11-13
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Titanium prepared platelet rich fibrin (T-PRF) placed in periodontal pocket and result will be seen after 6 weeks: After performing scaling and root planing (SRP), T-PRF will be prepare

Sponsors

Dr Subash Mehta
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Following patient will be included 1.Systemically healthy or with well-controlled systemic conditions (Diabetes Mellitus, Hypertension, Chronic kidney disease, cardiovascular disease) 2.With periodontitis Stage III Grade A (diagnosed according to the Classification of Periodontal and Peri-Implant Diseases and Conditions 2017) 3.With a 5 – 6 mm probing depth. 4.Patient willing to participate in the study.

Exclusion criteria

Exclusion criteria: Following patients will be excluded 1.History of systemic disease (Diabetes mellitus,Hypertension, Chronic kidney disease, cardiovascular disease) 2. Presence of active gingival disease 3.Pregnancy and lactation 4.History of any drug or systemic antibiotic usage affecting the periodontium for the past 3 months 5. History of periodontal surgery within the preceding six months 6.Current smokers 7.Teeth with untreated caries 8. Endodontic periapical lesions 9. Grade II or III mobility.

Design outcomes

Primary

MeasureTime frame
Reduction in probing pocket depth (PPD)Timepoint: 6 weeks

Secondary

MeasureTime frame
1.Clinical attachment level (CAL)gain. 2.Reduction in Plaque Index score 3.Reduction in Gingival Index score 4.Increase in Wound Healing Index sccore 5.Reduction in bleeding on probing (BOP)Timepoint: 6 weeks

Countries

India

Contacts

Public ContactDr Ashutosh Dixit

Aiims, Rishikesh

dixitdrashutosh@gmail.com9899818242

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026