Health Condition 1: O- Medical and Surgical
Conditions
Interventions
None listed
Sponsors
Iniya Shree
Eligibility
Inclusion criteria
Inclusion criteria: Patients eligible for this study were those aged 18 years or older who consented to participate in the trial. All participants were required to be on a regular regimen of low-dose aspirin (75-100 mg/day) or clopidogrel (75 mg/day) for primary prevention of cardiac complications. Additionally, the study focused on medically compromised patients who were deemed fit for simple extractions under local anaesthesia. Participants needed to have a bleeding time between 2 and 5 minutes, an Activated Partial Thromboplastin Time (APTT) of 30-40 seconds, and an International Normalized Ratio (INR) between 1.0 and 2.5, ensuring they had adequate blood coagulation parameters for safe surgical intervention. Finally, the study included patients who required simple tooth extractions, making them suitable candidates for the haemostatic treatments being evaluated.
Exclusion criteria
Exclusion criteria: Patients with the following conditions were excluded from the study to ensure the safety and validity of the results. Individuals under the age of 18 were excluded, as well as those who did not consent to participate. Patients who had an allergy to local anaesthetics or their constituents were also excluded, as this could interfere with the surgical procedure. Those with liver disease, or who were on combination antiplatelet drugs or NSAIDs that might interact with aspirin, were excluded due to the potential impact on bleeding risk and drug interactions. Additionally, patients with a history of serious haemorrhage following dental extractions were not included, as they might have an increased risk of complications. Patients who had discontinued antiplatelet medications prior to the procedure were also excluded. Other exclusion criteria included systemic conditions where tooth extraction is contraindicated, such as uncontrolled diabetes or hypertension, cancers like leukaemia or lymphoma, recent myocardial infarction or stroke (within the past 6 months), and blood disorders like haemophilia. Patients with end-stage renal disease, pregnant women in the 1st and 3rd trimesters, or those who had previously undergone radiation therapy in the extraction region were also excluded. These exclusions ensured that the study population was free from confounding factors that could compromise the outcomes or complicate the healing process.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessing the of efficacy of feracrylum and tranexamic acid as topical haemostatic agent in patients taking antiplatelets drugs undergoing dental extraction without stopping aspirin and clopidogrel.Timepoint: Assessing the of efficacy of feracrylum and tranexamic acid as topical haemostatic agent in patients taking antiplatelets drugs undergoing dental extraction without stopping aspirin and clopidogrel. | — |
Secondary
| Measure | Time frame |
|---|---|
| NilTimepoint: Nil | — |
Countries
India
Contacts
Public ContactIniya Shree
Meenakshi Ammal Dental College and Hospital
Outcome results
None listed