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Observation of Heart rhythm and Troponin changes before and after angioplasty in patients with heart disease

Dynamics of Heart Rate Variability (HRV) and serum Troponin before and after Ischemia-Reperfusion injury (IR) in patients undergoing Percutaneous Transluminal Coronary angioplasty (PTCA) An Observational Cohort study. - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/11/097270
Enrollment
60
Registered
2025-11-12
Start date
Unknown
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I21- Acute myocardial infarction Health Condition 2: I20- Angina pectoris Health Condition 3: I22- Subsequent ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Nil: Nil Intervention5: NIL: NIL

Sponsors

Mahatma Gandhi Medical College and Research Institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients 18-75 years, scheduled for Percutaneous Transluminal Coronary Angioplasty(PTCA) for stable or unstable angina and myocardial infarction.

Exclusion criteria

Exclusion criteria: 1. Patient with significantly impaired left ventricular (LV) function on echocardiography. 2. Coronary angiography confirmed incomplete occlusion of culprit vessels. 3. Patient who died during or 24 h after Percutaneous coronary intervention (PCI). 4. Active visceral hemorrhage. 5. Cardiogenic shock. 6. Liver and renal insufficiency. 7. Malignancy.

Design outcomes

Primary

MeasureTime frame
1. Heart Rate Variability (HRV) 2. Serum TroponinTimepoint: 1. Heart Rate Variability (HRV) Baseline (T0) Post procedure 1 hr (T1) Post procedure 6 hrs (T2) Post procedure 24 hrrs (T3) 2. Serum Troponin Baseline (Pre PTCA) 6 hrs post PTCA 12 hrs post PTCA 24 hrs post PTCA—

Secondary

MeasureTime frame
1. Demographics Age, BMI. 2. Myocardial infarction history Chest pain duration (weeks) Associated symptoms Past MI Pre hospital treatment like thrombolysis etc. 3.Comorbidities DM ,HTN , Hypothyroidism. 4.Medications 5. Investigations Hemoglobin Creatinine Hba1c% Potassium 6. Hemodynamic parameters Pulse rate SBP/DBP (MAP) SPo2 Perfusion index (PI) 7. ECG findings pre PTCA. 8. CAG findings & PTCA details. 9. Echo parameters Ejection fraction( pre- post ) Pulmonary artery systolic pressure ( pre-post) 10.Cath lab parameters Fluids Vasopressor use 11. IRI parameters Episodes of hypotension. Episodes of bradycardia Arrhythmias ( Bradycardia/ Tachycardia) Cardiac arrest. Timepoint: Baseline—

Countries

India

Contacts

Public ContactHemanth Kumar V R

Mahatma Gandhi Medical College and Research Institute Pondicherry.

anaesthesiology@mgmcri.ac.in9003550553

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026