Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Intravenous Fentanyl group (Group F): Patients in Group F will receive 1.5mcg/kg of Fentanyl Bolus. In Group F, fentanyl infusion at the rate of 0.25mcg/kg/hr. It will be continued intr
Sponsors
Nizams Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Patients belonging to American Society of Anaesthesiologists (ASA) Physical Status I to III, i.e.: • ASA I: Normal healthy individuals. • ASA II: Patients with mild systemic disease (e.g., controlled hypertension, controlled diabetes). • ASA III: Patients with severe systemic disease that is not incapacitating but limits activity (e.g., controlled cardiac or respiratory disease). Surgical procedure: Patients scheduled for elective composite resection and reconstruction surgery for head and neck malignancies under general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Patients who have BMI 35 2. Individuals with developmental or cognitive impairments that may hinder their ability to provide informed consent. 3. Pregnant or breastfeeding women. 4. Known allergies or hypersensitivity to morphine or fentanyl 5. Previous adverse reactions or complications associated with the use of either opioids. Patients with chronic opioid use or opioid tolerance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To systematically evaluate and compare the impact of intravenous morphine and fentanyl on hemodynamic response during composite resection and reconstruction surgeryTimepoint: At Baseline 1 minute after skin incision 5 minutes after skin incision 15minutes 30 minutes 45 minutes 60 minutes 90 minutes 120 minutes 150 minutes 180 minutes 210 minutes 240 minutes 270 minutes 300 minutes 330 minutes 360 minutes 390 minutes 420 minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the total anesthetic requirements, including the total dose of intraoperative fentanyl & sevoflurane consumption in patients receiving intravenous morphine compared to those receiving fentanyl during the surgical procedure. To analyze & compare the intraoperative hemodynamic fluctuations, including episodes of hypertension/ hypotension, Tachycardia/Bradycardia associated with the use of intravenous morphine versus fentanyl during composite resection & reconstruction surgery.Timepoint: at Baseline 1 minute after skin incision 5 minutes after skin incision 15minutes 30 minutes 45 minutes 60 minutes 90 minutes 120 minutes 150 minutes 180 minutes 210 minutes 240 minutes 270 minutes 300 minutes 330 minutes 360 minutes 390 minutes 420 minutes | — |
Countries
India
Contacts
Public ContactG Aravind
Nizams Institute of Medical Sciences
Outcome results
None listed