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Comparison of different pressure laparoscopic cholecystectomy for gall stone disease in terms of post operative pain and inflammatory markers

Comparison of inflammatory markers in low pressure pneumoperitoneum with deep neuromuscular block versus standard pressure pneumoperitoneum among patients undergoing laparoscopic cholecystectomy for gallstone disease: A Randomized Control Trial. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/097236
Enrollment
200
Registered
2025-11-11
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K802- Calculus of gallbladder without cholecystitis

Interventions

Intervention1: Laparoscopic cholecystectomy under low pressure (8-10mm Hg) with deep neuro-muscular block (NMB): Cisatracurium infusion will be given at rate of 1-3 mcg/kg/min in order to maintain PTC

Sponsors

AIIMS Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: BMI less than 30 ASA I,II Patient able to follow instructions

Exclusion criteria

Exclusion criteria: Any prior inflammatory conditions like Arthritis, Chronic skin diseases, IBD Pregnancy

Design outcomes

Primary

MeasureTime frame
Difference in inflammatory marker levels between the 2 groups i.e. IL-6, IL-1,IL-17,TNF alpha, WBC, ESR, CRP,Albumin, cortisol, Hb, platelet countTimepoint: baseline, 24 hours post surgery—

Secondary

MeasureTime frame
Pain scores by NPRS Incidence of Complications Length of hospital stay ConversionTimepoint: Pain scores by NPRS at 6, 24 hours Incidence of Complications during surgery, upto 1 day post operatively Length of hospital stay at discharge Conversion during surgery—

Countries

India

Contacts

Public ContactAnkita Singh

All India Institute of Medical Sciences, Delhi

ankitasingh05@gmail.com9968633853

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026