Aloe vera gel alone vs Aloe vera and Mangosteen gel combination in the treatment of gum disease

Comparative evaluation of efficacy of Mangosteen–Aloe vera gel combination versus Aloe vera gel alone as an adjunct to scaling and root planing in chronic periodontitis: A Split-mouth randomized controlled clinical trial - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/11/097211

Enrollment

Registered

2025-11-11

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Mangosteen and Aloe vera gel : Placement of Mangosteen and Aloe Vera gel combination in periodontal pocke

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age group: 25 to 60 years. 2. Systemically healthy patients (no known systemic diseases that affect periodontal health, e.g., diabetes, immunocompromised conditions). 3. Presence of chronic periodontitis diagnosed according to the 2017 World Workshop classification (Stage II–III, Grade B). 4. Presence of equal to or more than 2 sites/teeth with probing pocket depth (PPD) 4–7 mm. 5. No periodontal therapy or antibiotic use in the last 6 months. 6. Willingness to participate, maintain oral hygiene, and return for follow-up visits.

Exclusion criteria

Exclusion criteria: 1. Systemic diseases or conditions that may affect periodontal healing (e.g., uncontrolled diabetes, cardiovascular disease, immunosuppression, bleeding disorders). 2. Pregnant or lactating women 3. Smokers and tobacco users 4. Patients on immunosuppressive, anti-inflammatory, or antibiotic therapy within the last 6 months. 5. History of allergy or hypersensitivity to Aloe vera, Mangosteen, or herbal preparations. 6. Patients unwilling or unable to comply with study protocol and follow-up schedule.

Design outcomes

Primary

Measure	Time frame
1. Plaque Index (P.I.) (Tureskey-Gilmore-Glickman Modification of Quigley Hein) 2. Gingival Index (G.I.) (Loe and Silness, 1963) 3. Probing Pocket Depth (PPD) 4. Clinical Attachment Level (CAL)Timepoint: Baseline (post scaling), 1-month post-scaling. And 3 months post scaling	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Mala Dixit Baburaj

Nair Hospital Dental College

maladixit25@gmail.com9223340938

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026