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A study to compare the Effect of nebulisation with magnesium sulphate and lignocaine hydrochloride for attenuating hemodynamic response to laryngoscopy and endotracheal intubation in patients undergoing surgery under general anaesthesia

Effect of nebulisation with magnesium sulphate and lignocaine hydrochloride for attenuating hemodynamic response to laryngoscopy and endotracheal intubation in patients undergoing surgery under general anaesthesia: a randomised controlled trial - NIL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/097197
Enrollment
78
Registered
2025-11-11
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K812- Acute cholecystitis with chronic cholecystitis Health Condition 2: K381- Appendicular concretions Health Condition 3: K800- Calculus of gallbladder with acutecholecystitis Health Condition 4: K811- Chronic cholecystitis Health Condition 5: K380- Hyperplasia of appendix Health Condition 6: K820- Obstruction of gallbladder Health Condition 7: K822- Perforation of gallbladder

Interventions

Intervention1: Group M will receive 50% magnesium sulphate nebulisation Group L will receive 2% lignocaine hydrochloride nebulisation. Route is Inhalational. : Group M Patients will receive dose of 2

Sponsors

Ajitesh sutradhar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients of age group 18 to 65 years. 2. Patients of either sex 3. Patients of American Society of Anaesthesiologists (ASA) physical status grade I or II. And Mallampati grade I and II

Exclusion criteria

Exclusion criteria: 1. Allergy to any of the study drugs. 2. Patients with history of recent respiratory infection 3. Patients with history of chronic obstructive pulmonary disease, asthma 4. BMI more than 30 5. Patients with severe uncontrolled hypertension, ischaemic heart disease, pre-eclampsia 6. Anticipated difficult intubation 7. Patients under medications which causes interaction with magnesium sulphate or lignocaine hydrochloride 8. Patient refusing to give consent

Design outcomes

Primary

MeasureTime frame
hemodynamic stress response following direct laryngoscopy and endotracheal intubationTimepoint: Baseline Immediately after nebulisation Immediately after endotracheal intubation 5 min after endotracheal intubation 10 min after endotracheal intubation 15 min after endotracheal intubation—

Secondary

MeasureTime frame
post operative sore throat assessmentTimepoint: At the time of extubation, 4 hours,8 hours, 12 hours,24 hours following extubation—

Countries

India

Contacts

Public ContactAjitesh Sutradhar

Professor, Department of Anaesthesiology, Regional institute of medical sciences

drlongjam@gmail.com9436036407

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026