Health Condition 1: M171- Unilateral primary osteoarthritisof knee
Conditions
Interventions
Intervention1: Experimental group: Platelet-Rich Plasma + Supervised Strengthening Exercise Program: Participants in this group will receive three intra-articular PRP injections at weekly intervals (W
Sponsors
Sree Pallob
Jashore University of Science and Technology Jashore Bangladesh
Eligibility
Inclusion criteria
Inclusion criteria: Participants aged fifty years or older with a clinical diagnosis of knee osteoarthritis for at least six months according to the American College of Rheumatology criteria will be included. Eligible individuals must report an average knee pain score of four or higher on an eleven-point numerical rating scale over the past week and show mild to moderate radiographic tibiofemoral osteoarthritis defined as Kellgren and Lawrence grade two or three. All participants must provide informed consent and agree to participate in the eight-week study intervention.
Exclusion criteria
Exclusion criteria: Participants will be excluded if they show greater lateral than medial joint space narrowing on radiographs. Other exclusion criteria include the presence of systemic or inflammatory diseases, a history of glucocorticoid injection within the past three months, hyaluronic acid injection within the past six months, previous treatment with autologous blood products or stem cell therapy, platelet count one hundred fifty thousand per microliter or lower, bleeding disorders, or ongoing anticoagulant therapy. For bilateral knee osteoarthritis, only the most symptomatic knee will be treated.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measure pain using the Numeric Pain Rating Scale (NPRS)Timepoint: At baseline, 8 weeks and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| functional performance using the WOMAC index, range of motion by Goniometer, measure lower limb muscle strength through Hand held digital dynamometer and functional mobility with the Timed Up and Go (TUG).Timepoint: At baseline, 8 weeks and 6 months | — |
Countries
Bangladesh
Contacts
Public ContactDr Md Zahid Hossain
Jashore University of Science and Technology
Outcome results
None listed