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Biomarkers for bleeding, thrombosis and infection in patients on veno-arterial extracorporeal membrane oxygenation

Relationship between the dynamic trajectory of biomarkers for bleeding, thrombosis and infection in patients on veno-arterial extracorporeal membrane oxygenation and their causal association with ICU mortality - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/097145
Enrollment
100
Registered
2025-11-11
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I998- Other disorder of circulatory system

Interventions

Intervention1: Biomarkers ROTEM parameters, Platelet reactivity, D Dimer, Fibrinogen, Tumor Necrosis Factor alpha, High sensitivity C Reactive Protein, Procalcitonin, Interleukin 6, Neutrophil Lympho

Sponsors

Journal of Cardiac Critical Care The Simulation Society Research fund
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients from age birth till 50 years Either gender Undergoing elective cardiac surgery on cardiopulmonary bypass requiring integrated VA ECMO

Exclusion criteria

Exclusion criteria: Emergency cardiac surgeries or Re-do surgeries ECMO duration less than 24h Pre-existing coagulopathies Pre-existing liver or kidney or neurological dysfunction Pre-existing systemic infection Errors in detection of biomarkers or incomplete detection of biomarkers needed for analysis Lack of consent from the patient

Design outcomes

Primary

MeasureTime frame
Mortality on VA-ECMO in ICU and its correlation to the levels of various biomarker levels.Timepoint: Samples will be collected at baseline followed by 24h followed by 72h and at 7 days after ECMO initiation depending on the survival—

Secondary

MeasureTime frame
Drain output in first 24 hours in ICUTimepoint: at first 24h;Blood transfusion requirement on ECMO in ICUTimepoint: Total blood and blood product transfusion from beginning till weaning or mortality on ECMO;Duration of mechanical ventilation in ICUTimepoint: From initiation of ECMO till weaning from mechanical ventilation;Antibiotic requirement and incidence of sepsisTimepoint: From ECMO initiation till weaning from ECMO;Vasoactive Inotropic ScoreTimepoint: Calculated at baseline followed by 24h followed by 72h and at 7 days after ECMO initiation depending on the survival;Correlation between biomarkers for bleeding, thrombosis and infection.Timepoint: Samples will be collected at baseline followed by 24h followed by 72h and at 7 days after ECMO initiation depending on the survival—

Countries

India

Contacts

Public ContactDr Poonam Malhotra Kapoor

All India Institute of Medical Sciences New Delhii

mehta.khushboo1994@gmail.com8128529063

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026