This study compares how well dexmedetomidine works when given through the nose versus through a vein to control the rise in heart rate and blood pressure that happens during laryngoscopy and tube insertion in patients who are under general anaesthesia.

A clinical study comparing effectiveness of intranasal versus intravenous dexmedetomidine for attenuation of hemodynamic responses of laryngoscopy and endotracheal intubation n patients undergoing general anaesthesia. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/11/097139

Enrollment

Registered

2025-11-10

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intranasal Dexmedetomidine: inj. Dexmedetomidine 1mcg per kg given intranasally Control Intervention1: Intravenous Dexmedetomidine: Inj. Dexmedetomidine 0.5 mcg per kg given intravenous

Eligibility

Inclusion criteria

Inclusion criteria: ASA (American Society of Anesthesiologists) grade 1 and 2

Exclusion criteria

Exclusion criteria: Patient refused to participate Patient with known allergy and hypersensitivity to study drug

Design outcomes

Primary

Measure	Time frame
MAP (Mean arterial pressure) Heart Rate Systolic Blood Pressure Diastolic Blood PressureTimepoint: Baseline,10 minute, 20 minute, 30 minute, 40 minute, At Induction, At laryngoscope and Intubation, 1minute, 2 minute, 3minute, 4 minute, 7 minute, 10 minute.	—

Secondary

Measure	Time frame
Post-operative sedation(Ramsay sedation score)Timepoint: Baseline, At Intubation, 1 Hour, 2 Hour, 4 Hour, 6 Hour.	—

Countries

India

Contacts

Public ContactPAVANKUMAR S HANDRAL

Subharti Medical College

dr.manojbansal7@gmail.com7500693131

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026