Health Condition 1: N185- Chronic kidney disease, stage 5
Conditions
Interventions
Intervention1: Presential Forte Prebiotic & Probiotic Capsule for Gut Health: Dosage: 1 capsule/day containing Bifidobacterium longum (15Billion Spores) + Fructo Oligosaccharide (100mg) + Lactobacillu
Sponsors
Sangeeth Kumar Indu Kumar
Believers Church Medical College Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Adults aged 18 to 70 years with diagnosed chronic kidney disease (CKD). Patients undergoing maintenance hemodialysis for at least 12 weeks. Patients who have not used antibiotics or probiotics in the past 4 weeks. Individuals capable of giving informed consent to participate. Healthy age and sex matched individuals without chronic illness will also be enrolled as controls.
Exclusion criteria
Exclusion criteria: PHASE: 1 Exclusion Criteria Patients with Crohn’s disease, CVD, uncontrolled hypertension, ulcerative colitis, HIV/AIDS/liver disease, previous renal transplant, irritable bowel syndrome Pregnant or nursing women were also excluded Recent infections or hospitalisation Liver disease, malignancy, or autoimmune conditions Phase 2 Exclusion Criteria Allergy related to pre and probiotics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proof of disease specific microbial signatures or biomarkers associated with CKD patients on hemodialysis compared to the healthy controlsTimepoint: At baseline sample will be analyzed | — |
Secondary
| Measure | Time frame |
|---|---|
| Document the gut inflammation and systemic markers in patients with CKD before and after hemodialysisTimepoint: Pre and post intervention will be analyzed (0, 4 and 8 weeks);Document the impact of pre and probiotics supplementation and gut microbiome modulation in patients with CKD on hemodialysis. Timepoint: Pre and post intervention will be analyzed (0, 4 and 8 weeks) | — |
Countries
India
Contacts
Public ContactGiriprasad Venugopal
Believers Church Medical College Hospital
Outcome results
None listed