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comparison of two drugs to see which is more effective to reduce blood pressure and heart rate during general anesthesia

Comparison of Butorphanol with Buprenorphine in suppression of hemodynamic stress responses during General anesthesia - NIL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/097074
Enrollment
60
Registered
2025-11-07
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: injection Buprenorphine: single dose at start of general anesthesia 2.5 mcg/kg intravenous Control Intervention1: Butorphanol injection: single dose at start of general anesthesia 20 mc

Sponsors

RAJIV GANDHI INSTITUTE OF MEDICAL SCIENCES (RIMS), ADILABAD.
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age group between 18 to 70 years of both gender. Patient undergoing Elective surgeries under general anesthesia. ASA physical status I/II

Exclusion criteria

Exclusion criteria: Patients on opioids upto 2 weeks prior to surgery Obese patients, Difficult airway Patients on hypnotics and antidepressants with neurologic disorders Patients with moderate to severe respiratory and cardiac diseases Severe renal and hepatic impairment.

Design outcomes

Primary

MeasureTime frame
To Compare the Efficacy of Suppression of hemodynamic response of Butorphanol with Buprenorphine during intubation and extubationTimepoint: baseline, 1 hour, 2 hours and 3 hours—

Secondary

MeasureTime frame
Post operative Analgesia and Sedation Emergence Delirium Nausea and Vomiting.Timepoint: 10 min after surgery 2 hrs after surgery 6 hrs after surgery—

Countries

India

Contacts

Public ContactDr Tarun Teja Nagelly

RAJIV GANDHI INSTITUTE OF MEDICAL SCIENCES (RIMS), ADILABAD.

stephenshirley2025@gmail.com9371231434

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026