Health Condition 1: G540- Brachial plexus disorders
Conditions
Interventions
Intervention1: distal nerve injection: 1ml of cell suspension will be injected into the distal nerve using 27G needle intraoperatively single sitting at time of surgery. total duration : single intra
Sponsors
Department of burns plastic and reconstructive surgery
Department of Biochemistry
Eligibility
Inclusion criteria
Inclusion criteria: patients diagnosed with Pan or extended traumatic upper upper trunk brachial plexus injury of less than 7 months requiring surgical repair namely oberlins repair Spinal accessory to Supra spinatous nerve transfer repair via anterior of posterior approach Intercostal nerve to median nerve transfer intercostal nerve to musculocutaneous nerve transfer patients consenting to intra operative bone marrow derived stem cell application at the nerve reapir site and distal nerve No history of malignancies or active infection ability to provide written informed consent and comply with follow up assessments
Exclusion criteria
Exclusion criteria: patients with a history of autoimmune disease or significant immunosuppression presence of systemic conditions affecting nerve reapair outcomes like uncontrolled diabetes and severe vascular disease pregnant of lactating women previous brachial plexus repair surgeries or alternative regenrative therapies for the same injury
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| recruitment rate consent rate retention rate BMSC processing time protocol adherence adverse events bone marrow site painTimepoint: arrival,admission, Post op day 0,3, 1 month, 3 month, 6 month and 9 month | — |
Secondary
| Measure | Time frame |
|---|---|
| muscle strength MRC grading goniometric measurements of shoulder abduction and elbow flexion in degree 10 cm VAS NCS MRITimepoint: at recruitment, 1 month, 3 month, 6 month, 9 month at recruitment,1 month, 3 month, 6 month, 9 month at recruitment, 3 month, 6 month, 9 month 3 month, 6 month, 9 month 6 month, 9 month 6 month, 9 month | — |
Countries
India
Contacts
Public ContactShivam Sharma
All India Institute Of Medical Sciences
Outcome results
None listed