Health Condition 1: F101- Alcohol abuse Health Condition 2: F102- Alcohol dependence
Conditions
Interventions
Intervention1: Dexmedetomidine + Lorazepam: Intravenous infusion of Dexmedetomidine 0.2mcg/kg to 0.7mcg/kg for 2 days and Oral Lorazepam fixed tapering dose of 2mg, 6th hourly for 2 days, 2mg 8th hou
Sponsors
Nimisha George
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients admitted in ICU with medical or surgical illness with features of alcohol withdrawal syndrome or alcohol withdrawal delirium as per DSM V definition at the time of ICU admission
Exclusion criteria
Exclusion criteria: Active status epilepticus,Pregnancy or lactation,Known allergy or adverse response to any of the study medications,Severe hepatic impairment (Child Pugh C ),Serious central nervous system pathology (acute stroke, uncontrolled seizures, severe dementia),Heart rate less than 50 per min,Second- or third degree heart block,Systolic blood pressure less than 90 mm Hg despite continuous infusions of more than o.8microgram per hour infusion of noradrenaline before allocation to study group,Previous randomization into this study,those who are not expected to stay in ICU for less than 48 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparing delirium free days in intervention group and control group.Timepoint: Delirium free days - 7 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparing mMINDS score, comparing length of ICU stay ( in days),comparing ventilator free days,comparing the use of additional sedatives to achieve RASS 0 to -2Timepoint: mMINDS at the time of admission,after 48hours. Length of ICU stay till discharge from ICU Ventillator free days till discharge from ICU Use of additional sedatives in first 7 days | — |
Countries
India
Contacts
Public ContactNimisha George
Jubilee mission medical college and research institute
Outcome results
None listed