Comparison of two drugs sugammadex and neostigmine that reverse the muscle relaxation in laparoscopic surgeries in adults.

A randomized controlled trial of sugammadex versus neostigmine for the reversal of vecuronium induced neuromuscular blockade in adults - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/11/096991

Enrollment

100

Registered

2025-11-06

Start date

Unknown

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: K80-K87- Disorders of gallbladder, biliary tract and pancreas Health Condition 3: K40-K46- Hernia Health Condition 4: K35-K38- Diseases of appendix

Interventions

Intervention1: Sugammadex: 2mg/kg of Total Body Weight (TBW) single dose at the end of surgey Control Intervention1: Neostigmine: 50mcg/kg of Total Body Weight (TBW) single dose at the end of surgey

Eligibility

Inclusion criteria

Inclusion criteria: 1. American Society of Anesthesiologist Physical Status classification I,II 2. All elective and emergency laparoscopic surgeries

Exclusion criteria

Exclusion criteria: Known allergy or contraindications to Sugammadex or Neostigmine History of neuromuscular disorders Severe renal / hepatic impairment Cardiac disease Pregnancy/Breastfeeding

Design outcomes

Primary

Measure	Time frame
1.Compare time taken for complete reversal of vecuronium induced neuromuscular blockade of Sugammadex and NeostigmineTimepoint: Immediate postoperatively till TOF ratio more than 0.9	—

Secondary

Measure	Time frame
1. Time taken for recovery from T2- T4 2.Clinical signs of recovery - 5 sec head lift, leg lift 3. Incidence of residual curarisation 4. Incidence of complicationsTimepoint: 1. Time taken for recovery from T2 (at the time of administration of reversal agent) - T4 (Time of 4th response in TOF) 2. Immediate postoperatively to check for clinical signs of recovery 3. Check for hypoxia, respiratory distress, residual paralysis immediate postoperatively 4. To look for side effects of the drugs used immediately after administration at the end of surgery	—

Measure

Time frame

1. Time taken for recovery from T2- T4 2.Clinical signs of recovery - 5 sec head lift, leg lift 3. Incidence of residual curarisation 4. Incidence of complicationsTimepoint: 1. Time taken for recovery from T2 (at the time of administration of reversal agent) - T4 (Time of 4th response in TOF) 2. Immediate postoperatively to check for clinical signs of recovery 3. Check for hypoxia, respiratory distress, residual paralysis immediate postoperatively 4. To look for side effects of the drugs used immediately after administration at the end of surgery

—

Countries

India

Contacts

Public ContactDr PREMKUMAR M

Dr Mehta Multi Speciality Hospitals

premsyd@gmail.com9884739206

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026