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A study comparing skin needling with tofacitinib ointment(helps with repigmentation) and skin needling with topical 5-fluorouracil cream(helps with repigmentaion) in patients with vitiligo to help with repigmentation.

Comparing the Efficacy of Micro-needling with Topical Tofacitinib vs Micro-needling with Topical 5-Fluorouracil in Vitiligo:An Analytical Prospective Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/11/096990
Enrollment
36
Registered
2025-11-06
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L80- Vitiligo

Interventions

Intervention1: Microneedling with Tofacitinib: Microneedling will be done on the vitiliginous patch and then tofacitinib ointment(2%) will be applied topically after pin point bleeding is achieved pos

Sponsors

PIYUSHA GUPTA
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: •Cases more than 18 years of age •Patients who have given informed consent •Stability of lesions for at least 1 year •Presence of vitiliginous lesions over acral area not responding to any treatment modality

Exclusion criteria

Exclusion criteria: •Pregnant or lactating cases •Patients with a history of unstable vitiligo lesions •Cases with history of keloidal tendency •Patients with a history of Koebner phenomenon. •Patients not consenting to be a part of the study

Design outcomes

Primary

MeasureTime frame
To compare the efficacy of topical tofacitinib with microneedling vs topical 5 – fluorouracil with microneedling in cases of vitiligoTimepoint: 1 month—

Secondary

MeasureTime frame
To assess the patient satisfaction in post-procedural settings using the vitiligo noticeability scaleTimepoint: 2 months;To determine the post procedural regimentation in both arms through the Pixel Assisted Regimentation Assessment in Vitiligo (PARAV) application.Timepoint: 1 month;To validate the Pixel Assisted Regimentation Assessment in Vitiligo (PARAV) application.Timepoint: 1 year—

Countries

India

Contacts

Public ContactPIYUSHA GUPTA

Dr.Vithalrao Vikhe Patil Foundations Medical College and Hospital

ishavanarase@gmail.com7738880792

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026